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Human & Experimental Toxicology, Vol. 25, No. 12, 705-713 (2006)
DOI: 10.1177/0960327106073827

Protective effects of Gingko biloba on thioacetamide-induced fulminant hepatic failure in rats

M M M Harputluoglu

U Demirel

Department of Gastroenterology, Inonu University Medical Faculty, Malatya, Turkey

H Ciralik

Department of Pathology, Sutcuimam University Medical Faculty, Kahramanmaras, Turkey

I Temel

S Firat

Department of Biochemistry, Inonu University Medical Faculty, Malatya, Turkey

C Ara

Department of General Surgery, Inonu University Medical Faculty, Malatya, Turkey

M Aladag

M Karincaoglu

F Hilmioglu

Department of Gastroenterology, Inonu University Medical Faculty, Malatya, Turkey

Gingko biloba (GB) has antioxidant and platelet-activating factor (PAF) antagonistic effects. We investigated the protective effects of GB on thioacetamide (TAA)induced fulminant hepatic failure in rats. Fulminant hepatic failure was induced in treatment groups by three intraperitoneal (ip) injections of TAA (350 mg/kg) at 24-hour intervals. Treatments with GB (100 mg/kg per day, orally) and N-acetylcysteine (20 mg/kg twice daily, sc) were initiated 48 hours prior to TAA administration. The liver was removed for histopathological examinations. Serum and liver thiobarbituric acid-reactive substance (TBARS) levels were measured for assessment of oxidative stress. Liver necrosis and inflammation scores and serum and liver TBARS levels were significantly higher in the TAA group compared to the control group (P <0.001,<0.001, 0.001,<0.001, respectively). Liver necrosis and inflammation scores and liver TBARS levels were significantly lower in the GB group compared to the TAA group (P <0.001,<0.001 and 0.01, respectively). GB ameliorated hepatic damage in TAA-induced fulminant hepatic failure. This may be due to the free radical-scavenging effects of GB.

Key Words: fulminant hepatic failure • Gingko biloba • oxidative stress • platelet activating factor • thioacetamide


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