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Acute iron poisoning in adult female

Department of Internal Medicine, Medical University of Wroclaw, Wroclaw, Poland, annaskoc{at}ak.am.wroc.pl

D. Kwiecinska

Department of Internal Medicine, Medical University of Wroclaw, Wroclaw, Poland

M. Kielbinski

Department of Hematology, Medical University of Wroclaw, Wroclaw, Poland

M. ukaszewski

Department of Anaesthesiology and Intensive Therapy, Medical University of Wroclaw, Wroclaw, Poland

We report a case of a 27-year-old female with anemia, treated with high dose oral and parenteral iron therapy (within 20 days, the patient received a total dose of 4 g Fe+2 orally and 700 mg Fe+2 iv and im), and developed clinical manifestations characteristic of acute iron poisoning. Initial gastrointestinal symptoms and hypotension were followed by signs of mitochondrial toxicity: high leucocytosis, shock, multi-organ failure and disseminated intravascular coagulation. We discuss the difficulties in diagnosing acute iron poisoning. The initial low total iron blood capacity and high ferritin level, as well as the typical sequence of symptoms, supported the diagnosis. The patient avoided fatal consequences, probably due to the administration of iron doses over an extended period of time. However, cumulative effects led to the apparent iron toxicity. After 2 weeks of treatment, the patient was discharged from hospital in good condition. Human & Experimental Toxicology (2007) 26, 663-666

Key Words: acute poisoning • desferrioxamine • iron • SIRS

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Human & Experimental Toxicology, Vol. 26, No. 8, 663-666 (2007)
DOI: 10.1177/0960327107071854


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Skoczynska, A. Articles by Lukaszewski, M. Search for Related Content PubMed PubMed Citation Articles by Skoczynska, A. Articles by Lukaszewski, M. Social Bookmarking                         What's this?