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Poisoning with 1-propanol and 2-propanol

M Vujasinovi

Department of Internal Medicine, Topolica Hospital, Topolica, Slovenia

M Koar

Department of Pulmology, Topolica Hospital, Topolsica, Slovenia

K Kramer

Department of Pulmology, Topolica Hospital, Topolsica, Slovenia

M Bunc

Department for Cardiology, University Medical Centre Ljubljana, Ljubljana, Slovenia; Medical Faculty, Institute for Pathophysiology, Ljubljana, Slovenia

M Brvar

Medical Faculty, Institute for Pathophysiology, Ljubljana, Slovenia; Poison Control Centre, University Medical Centre Ljubljana, Ljubljana, Slovenia

1-Propanol and 2-propanol are isomers of an alcohol with three carbons. They are colorless liquids with a sweet odor. 1-Propanol is metabolized by alcohol dehydrogenase to propionic acid and presents with metabolic acidosis and elevated anion gap, whereas 2-propanol is metabolized by alcohol dehydrogenase to acetone and presents with rapidly developing (within 3–4�h after exposure) ketosis and ketonuria but without metabolic acidosis. We report a patient who simultaneously ingested a lethal dose of 1-propanol and 2-propanol as a hand disinfectant in hospital. The patient lost consciousness and stopped breathing within half an hour after ingestion. He was intubated and artificially ventilated. Initial laboratory results showed mixed acidosis with elevated anion gap, but ketonuria appeared only 12�h after admission and 6�h following the regaining of consciousness. Therefore, laboratory results in simultaneous poisoning with two isomers of alcohol are not just a sum of laboratory results obtained in isolated poisoning with each isomer because they influence each other’s metabolism: 1-propanol retards the metabolism of 2-propanol to acetone. In conclusion, 1-propanol and 2-propanol poisoning presents early with mixed acidosis and elevated anion gap and only later with ketonuria.

Key Words: 1-propanol • 2-propanol • coma • isopropyl alcohol • n-propanol • poisoning

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Human & Experimental Toxicology, Vol. 26, No. 12, 975-978 (2007)
DOI: 10.1177/0960327107087794


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Vujasinovic, M Articles by Brvar, M Search for Related Content PubMed PubMed Citation Articles by Vujasinovic, M Articles by Brvar, M Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB ISOPROPANOL N-PROPANOL Social Bookmarking                         What's this?