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Survey of Amanita phalloides poisoning: clinical findings and follow-up evaluation

M Kenová

Department of Occupational Medicine, Toxicological Information Centre, Charles University, General University Hospital, Prague, Czech Republic

D Pelclová

Department of Occupational Medicine, Toxicological Information Centre, Charles University, General University Hospital, Prague, Czech Republic

T Navrátil

J. Heyrovsk Institute of Physical Chemistry, AS CR, v. v. i., Prague, Czech Republic

The aim of our study was to evaluate the severity of hepatic and kidney damage with a focus on their reversibility, and to analyze the prognostic factors following Amanita phalloides poisoning based on calls made to the Czech Toxicological Information Centre. A variety of clinical and laboratory parameters were collected. Student’s t-test and Fisher’s test were used for statistical analysis. Amanita phalloides poisoning was verified in 34 cases (5 children, 29 adults). The following findings emerged: vomiting (76%), diarrhea (62%), hepatic failure (24%), and renal failure (11%). Two patients died on the fifth day after mushroom ingestion. In 18 patients, all serum levels normalized by the time of discharge; in 10 patients up to 7.3�months on average after discharge. Five patients did not comply with follow-up. Renal damage persisted in only one patient, 19�months after discharge. In conclusion, the interval to recovery from hepatic and renal damage by the time of discharge depended on a decrease in the prothrombin index and an increase in serum transaminase and bilirubin levels. Recovery was favorable in all subjects who survived the acute phase of poisoning, except in one patient with a solitary kidney.

Key Words: death cap • hepatotoxicity • nephrotoxicity • toxicological information centre

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Human & Experimental Toxicology, Vol. 26, No. 12, 955-961 (2007)
DOI: 10.1177/0960327107085832


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