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Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats

Faculty of Pharmacy, Department of Pharmacology, Jamia Hamdard, New Delhi, India

U Bhandari

Faculty of Pharmacy, Department of Pharmacology, Jamia Hamdard, New Delhi, India

KK Pillai

Faculty of Pharmacy, Department of Pharmacology, Jamia Hamdard, New Delhi, India

This study was designed to investigate the effect of oral curcumin pretreatment (200 mg/kg) on isoproterenol-induced myocardial injury in rats. Isoproterenol (85 mg/kg, s.c., in two divided doses at 24 h intervals) administration induced a statistically significant increase (P < 0.01) in serum lactate dehydrogenase, creatine kinase, aspartate transaminase, and alanine transaminase activities and significant increase (P < 0.01) in myocardial lipid peroxides levels as compared to vehicle control rats. Furthermore, significant depletion (P < 0.01) of myocardial endogenous antioxidants viz. superoxide dismutase, catalase, and tissue glutathione levels were also found in the pathogenic control group, that is, isoproterenol only treated animals. Curcumin (200 mg/kg) pretreatment for 20 days in isoproterenol treated rats significantly lowered (P < 0.01) the serum lactate dehydrogenase, creatine kinase, aspartate transaminase, alanine transaminase, and myocardial lipid peroxides levels and increased the levels of myocardial endogenous antioxidants (superoxide dismutase, catalase, and tissue glutathione) as compared to pathogenic control rats. Furthermore, histological examination of rat’s heart section confirmed myocardial injury with isoproterenol administration and near normal pattern with curcumin pretreatment. The results of our study provide clear evidence that the curcumin pretreatment enhances the antioxidant defense against isoproterenol-induced oxidative myocardial injury in rats and exhibit cardioprotective property.

Key Words: curcumin • isoproterenol • lipid peroxides • myocardial injury

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Human & Experimental Toxicology, Vol. 26, No. 12, 933-938 (2007)
DOI: 10.1177/0960327107085835


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nazam Ansari, M Articles by Pillai, K. Search for Related Content PubMed PubMed Citation Articles by Nazam Ansari, M Articles by Pillai, K. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CURCUMIN Medline Plus Health Information Heart Attack Social Bookmarking                         What's this?