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Human & Experimental Toxicology
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Acute Poisoning with Methidathion: A Case

R. Zoppellari

Department of Anaesthesia and Critical Care, S. Anna Hospital, 44100 Ferrara, Italy

L. Targa

Department of Anaesthesia and Critical Care, S. Anna Hospital, 44100 Ferrara, Italy

P. Tonini

Department of Anaesthesia and Critical Care, S. Anna Hospital, 44100 Ferrara, Italy

R. Zatelli

Department of Anaesthesia and Critical Care, S. Anna Hospital, 44100 Ferrara, Italy

An acute poisoning in a 50-year-old man who ingested approximately 6.2 g of the phosphorus ester methidathion is described. The patient was treated with three haemoperfusions 23, 44 and 115 h after ingestion, with continuous gastric lavage, atropine and pralidoxime administration and with prolonged mechanical ventilation.

Haemoperfusion was an ineffective epuration technique since it removed only 0.22% of the ingested methidathion.

The clinical course wavered because of a probable redistribution of phosphorus ester from fat to blood. A plasma level higher than 100 µg l-1 was associated with the most serious phases. Methidathion was present in the plasma until the sixth day, in the urine until the seventh and in the gastric juice until the eighth. Its absence in the fat biopsy made on the tenth day was an aid to therapy.

The phosphorus ester did not inhibit lymphocyte neuropathy target esterase (NTE), neither did it induce development of delayed polyneuropathy.

Human & Experimental Toxicology, Vol. 9, No. 6, 415-419 (1990)
DOI: 10.1177/096032719000900610
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This article has been cited by other articles:


Home page
 Hum Exp ToxicolHome page
C. Ozdemir, H. Kar, Y. Bilge, G. Batuk, and H. I. Batuk
Homicidal poisoning by injection of methidathion: The first ever report
Human and Experimental Toxicology, August 1, 2009; 28(8): 521 - 524.
[Abstract] [PDF]


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