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Phthalate Esters, Cystic Kidney Disease in Animals and Possible Effects on Human Health: A Review

Toxicology and Environmental Health Division, Department of Health, Hannibal House, Elephant and Castle, London SE1 6TE; UK

1 Phthalate esters are known to cause hepatic peroxisome proliferation in rodents and, after prolonged administration, hepatocarcinogenesis. Peroxisome proliferators as a group are hepatocarcinogenic. The mechanism is not known but it does not appear to involve a direct genotoxic element.

2 DEHP and DBP have been shown to cause renal cysts in rodents and they also produce renal peroxisome proliferation. There are no data to causally link the two phenomena.

3 Although renal cysts have been noted in haemodialysis patients and haemodialysis is a route of exposure to DEHP, there are no data to suggest a cause and effect relationship.

4 More studies are needed on the mechanism of renal cystogenesis.

Human & Experimental Toxicology, Vol. 9, No. 6, 397-401 (1990)
DOI: 10.1177/096032719000900607


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