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Cytogeneticity of Quinalphos and Methyl Parathion in Human Peripheral Lymphocytes

Institute of Genetics, Hospital for Genetic Diseases, Begumpet, Hyderabad-16, A.P., India

P.P. Reddy

Institute of Genetics, Hospital for Genetic Diseases, Begumpet, Hyderabad-16, A.P., India

O.S. Reddi

Institute of Molecular Biology and Biotechnology, Transgenet Biotek, Banjara Hills-2. Hyderabad, 34, A.P., India

1 Four different concentrations of quinalphos and methyl parathion were tested on human peripheral lymphocytes over different time periods, for the analysis of chromosomal aberrations and sister chromatid exchanges (SCEs).

2 A significant increase in chromosomal aberrations was observed when cells were treated with quinalphos for 48 and 72 h and a significant increase in SCEs was observed at all the concentrations and over all the time periods.

3 Methyl-parathion did not induce chromosomal aberrations but it did induce SCEs significantly over all time periods.

Human & Experimental Toxicology, Vol. 9, No. 6, 385-387 (1990)
DOI: 10.1177/096032719000900605


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