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Human & Experimental Toxicology
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Pre-embarkment Prognostication for Acute Paraquat Poisoning

Hiroshi Yamaguchi

Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba

Shigehito Sato

Department of Anesthesia, Tsuchiura Kyodo Hospital

Seiji Watanabe

Department of Anesthesia and Mito Saiseikai General Hospital, Japan

Hiroshi Naito

Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba

1 In order to assess which laboratory parameters could be related to the prognosis of patients with acute paraquat poisoning, we reviewed the medical records of 160 patients who had ingested paraquat in an attempt at suicide.

2 Serum creatinine and potassium concentrations, arterial blood bicarbonate and base excess levels, arterial blood pH, volume of paraquat ingested and the strength of the urinary paraquat qualitative test (sodium dithionate colour reaction) on admission in the surviving patients were significantly different from those of the patients who died within 48 h of ingestion.

3 The relationship of the quantity Eq1 defined as:

Eq1 = ([K +] x [HCO-3]) / ([Cre] x 0.088) (mEq l-1 )

against the interval of time after ingestion to admission (T) had a significant correlation with prognosis (P < 0.01). Patients with Eq1 > (1500 - 399 x LogT) had a 90% survival rate, Eq1: (930 - 399 x LogT) < Eq1 ≤ (1500 - 399 x LogT) 38% and Eq1 ≤ (930 - 399 x LogT) 3%, P < 0.01.

Human & Experimental Toxicology, Vol. 9, No. 6, 381-384 (1990)
DOI: 10.1177/096032719000900604
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