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Human & Experimental Toxicology
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Pharmacokinetics and Toxic Effects of Nifedipine in Massive Overdose

R.E. Ferner

Freeman Hospital, Newcastle-upon-Tyne NE7 7DN and

S. Monkman

Pharmacogenetics Research Unit, Department of Pharmacology, University of Newcastle-upon-Tyne NE2 4HH, UK

J. Riley

Freeman Hospital, Newcastle-upon-Tyne NE7 7DN and

S. Cholerton

Pharmacogenetics Research Unit, Department of Pharmacology, University of Newcastle-upon-Tyne NE2 4HH, UK

J.R. Idle

Pharmacogenetics Research Unit, Department of Pharmacology, University of Newcastle-upon-Tyne NE2 4HH, UK

D.N. Bateman

Freeman Hospital, Newcastle-upon-Tyne NE7 7DN and

A 57-year-old man took 30 � 20 mg nifedipine retarded release tablets. He developed hypotension, tachycardia and flushing, but remained in sinus rhythm. The concentration of nifedipine 10 h after overdose was 604 ?g 1-1, and of the M-I metabolite 110 ?g 1-1. Log concentration time curves were linear from 10-72 h for nifedipine, with a half-life of 7.5 h; and for M-I with a half-life of 8.2 h. On this evidence, oral absorption of nifedipine retarded release is complete by 10 h. There was no evidence of saturation of nifedipine or M-I metabolism, even at concentrations ten times above the therapeutic concentration.

Human & Experimental Toxicology, Vol. 9, No. 5, 309-311 (1990)
DOI: 10.1177/096032719000900507
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