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The Effect of the ?-Particle Emitter Astatine-211 in the Mouse at the Minimum Toxic Dose

Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 ORD, UK

S.A. Butler

Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 ORD, UK

A. Harrison

Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Harwell, Didcot, Oxon OX11 ORD, UK

The radioactive halogen astatine-211 was injected into mice in an amount producing minimal toxicity. Histopathological examination of tissues at intervals between 3 d and 16 weeks showed the following changes:

1 Radiation-induced necrosis and progressive fibrosis of the thyroid gland. The gland was reduced to 25% of its original mass with only a few relatively normal follicles persisting.

2 A small, temporary, reduction in peripheral blood lymphocytes, platelets and red cells and a significant persistant increase in polymorphs.

3 Severe reduction in reproductive cells in the testis with some signs of recovery at 16 weeks.

Human & Experimental Toxicology, Vol. 9, No. 5, 289-293 (1990)
DOI: 10.1177/096032719000900505


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