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Human & Experimental Toxicology
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Neutrophil Functions in Lead-Exposed Workers

A. Bergeret

Institut Universitaire de Medecine du Travail, 8 Avenue Rockefeller

E. pouget

Institut Universitaire de Medecine du Travail, 8 Avenue Rockefeller

R. Tedone

Laboratoire d'Immunotoxicologie Fondamentale et Clinique, INSERM U80-CNRS URA1177-UCBL, FacuIté de Médecine Alexis Carrel, 69008 Lyon, France

T. Meygret

Institut Universitaire de Medecine du Travail, 8 Avenue Rockefeller

R. Cadot

Institut Universitaire de Medecine du Travail, 8 Avenue Rockefeller

J. Descotes

Laboratoire d'Immunotoxicologie Fondamentale et Clinique, INSERM U80-CNRS URA1177-UCBL, FacuIté de Médecine Alexis Carrel, 69008 Lyon, France

Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemiluminescence was found to be slightly but not significantly altered in exposed workers. In contrast, chemotaxis using the agarose technique was significantly depressed. These results are in agreement with previous in-vitro findings. A further assessment of clinical consequences is warranted.

Human & Experimental Toxicology, Vol. 9, No. 4, 231-233 (1990)
DOI: 10.1177/096032719000900405
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