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Human & Experimental Toxicology
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Specific Anti-digoxin Fab Fragments: an Available Antidote for Proscillaridin and Scilliroside Poisoning?

A. Sabouraud

INSERM U26, Hopital Fernand Widal 200, Rue du Faubourg Saint-Denis 75475 Paris France

M. Urtizberea

INSERM U26, Hopital Fernand Widal 200, Rue du Faubourg Saint-Denis 75475 Paris France

N. Cano

INSERM U26, Hopital Fernand Widal 200, Rue du Faubourg Saint-Denis 75475 Paris France

R. Garnier

Centre Anti-poison, Hôpital Fernand Widal 200, Rue du Faubourg Saint-Denis 75475 Paris Cedex 10, France

J.M. Scherrmann

INSERM U26, Hopital Fernand Widal 200, Rue du Faubourg Saint-Denis 75475 Paris France

The purpose of this study was to evaluate the capacity of specific anti-digoxin Fab fragments to bind to and neutralize scilliroside and proscillaridin in acute poisoning. Apparent affinity constants were determined with values of 2.6 108M -1 for scilliroside and 3.8 107M-1 for proscillaridin. These results are in accordance with a possible in-vivo neutralization of these toxins.

Human & Experimental Toxicology, Vol. 9, No. 3, 191-193 (1990)
DOI: 10.1177/096032719000900313
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This article has been cited by other articles:


Home page
 JAMAHome page
J. Brubacher and R. S. Hoffman
Digoxinlike Toxicity and Death From a Purported Aphrodisiac-Reply
JAMA, April 3, 1996; 275(13): 988 - 988.
[Abstract] [PDF]


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