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Human & Experimental Toxicology
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Intravenous N-Acetylcysteine, Hepatotoxicity and Plasma Glutathione S-Transferase in Patients with Paracetamol Overdosage

G.J. Beckett

University Departments of Clinical Chemistry, The Royal Infirmary, Edinburgh EH3 9YW Scotland, UK

J.W. Donovan

The Regional Poisoning Treatment Centre, The Royal Infirmary, Edinburgh EH3 9YW, Scotland, UK, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

A.J. Hussey

University Departments of Clinical Chemistry, The Royal Infirmary, Edinburgh EH3 9YW Scotland, UK

A.T. Proudfoot

The Regional Poisoning Treatment Centre, The Royal Infirmary, Edinburgh EH3 9YW, Scotland, UK

L.F. Prescott

Clinical Pharmacology, The Royal Infirmary, Edinburgh EH3 9YW Scotland, UK, The Regional Poisoning Treatment Centre, The Royal Infirmary, Edinburgh EH3 9YW, Scotland, UK

The concentration of glutatione S-transferase B1 (GST B1) subunits was measured in sequential plasma samples taken at frequent intervals for 48 h from ten patients with severe paracetamol poisoning who were treated with intravenous N-acetylcysteine. No significant increase in plasma GST B1 concentration was observed over the study period and within 4 h of starting treatment with N-acetylcysteine there were significant decreases in plasma GST B1 concentrations. None of the patients subsequently developed significant liver damage. At the dose used for the treatment of paracetamol poisoning, N-acetylcysteine has no hepatotoxic effects.

Human & Experimental Toxicology, Vol. 9, No. 3, 183-186 (1990)
DOI: 10.1177/096032719000900311
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