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Zolpidem Intoxication Mimicking Narcotic Overdose: Response to Flumazenil

Emergency Department and Clinical Toxicology Unit

G. Debailleul

Central Laboratory of Toxicology, Erasme University Hospital, Brussels, Belgium

O. De Witte

Emergency Department and Clinical Toxicology Unit

R. Askenasi

Emergency Department and Clinical Toxicology Unit

Zolpidem is a recently introduced sleep-inducer which is thought to act on the central-type benzodiazepine receptors. This observation is the first report of drug poisoning with this compound. The toxic response was characterized by the development of a profound but short-lasting coma, associated with pin-point pupils and respiratory depression, as observed in a narcotic overdose. These clinical signs were not influenced by the administration of naloxone, but responded dramatically to flumazenil. Some analytical data on zolpidem toxicokinetics are presented.

Human & Experimental Toxicology, Vol. 9, No. 2, 105-107 (1990)
DOI: 10.1177/096032719000900209


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