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Human & Experimental Toxicology
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Human Metabolism of Arsenobetaine Ingested with Fish

R.M. Brown

Environmental and Medical Sciences Division, Harwell Laboratory, Didcot, Oxon OX11 ORA

D. Newton

Environmental and Medical Sciences Division, Harwell Laboratory, Didcot, Oxon OX11 ORA

C.J. Pickford

Environmental and Medical Sciences Division, Harwell Laboratory, Didcot, Oxon OX11 ORA

J.C. Sherlock

Food Science Division, Ministry of Agriculture, Fisheries & Food, Smith Square, London SW1P 3HX, UK

1 Six volunteers ingested 74As-labelled arsenobetaine with a fish meal. The retention and distribution of the tracer were studied by body radioactivity measurements.

2 The tracer became rapidly dispersed in soft tissues, with no major concentration in any localized organ or region.

3 In all subjects < 1% of the ingested activity remained in the body after 24 days.

4 Any losses from the skin were minor in relation to those by other routes of excretion.

Human & Experimental Toxicology, Vol. 9, No. 1, 41-46 (1990)
DOI: 10.1177/096032719000900109
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[Abstract] [Full Text] [PDF]


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