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Post-mortem Serum Concentration of Cantharidin in a Fatal Case of Cantharides PoisoningDepartments of Pharmacology, University of the Orange Free State, P.O. Box 339, Bloemfontein, 9300, South Africa
Departments of Pharmacology, University of the Orange Free State, P.O. Box 339, Bloemfontein, 9300, South Africa
Forensic Medicine, Medical Faculty, University of the Orange Free State, P.O. Box 339, Bloemfontein, 9300, South Africa A patient admitted to hospital died shortly after admission without a proper diagnosis having been made. Symptoms as well as the presence of a brown powder found in the possession of the deceased indicated the possibility of cantharidin intoxication. Cantharidin was positively identified by means of a GC/MS analysis, utilizing the selected ion monitoring technique (SIM), for m/z = 197.0813, (M+H+) for cantharidin, under positive chemical ionization conditions at a resolution of 7000 and a mass window of 30 ppm. Quantitation was done by means of a GC/MS SIM analysis of a toluene extract of acidified post-mortem serum under El+ conditions at a resolution of 3000, using clofibrate as internal standard and monitoring m/z = 128.0473 and 128.0029 for cantharidin and clofibrate respectively. The post-mortem serum was found to contain cantharidin at a concentration of 72.3 ng/ ml whilst the cantharides powder contained 0.87% cantharidin.
Human & Experimental Toxicology, Vol. 9, No. 1,
35-40 (1990) This article has been cited by other articles:
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