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Human & Experimental Toxicology
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Intracellular Localization of Cerium. A Microanalytical Study using an Electron Microprobe and Ionic Microanalysis

J.P. Berry

Service Commun 27 de l'Institut National de la Santé et de la Recherche Médicale - Faculté de Médecine 8, rue du Général Sarrail 94000 Creteil

R. Masse

Laboratoire de Toxicologie Expérimentale, B.P. 6 - 92260 Fontenay Aux Roses, France

F. Escaig

Service Commun 27 de l'Institut National de la Santé et de la Recherche Médicale - Faculté de Médecine 8, rue du Général Sarrail 94000 Creteil

P. Galle

Service Commun 27 de l'Institut National de la Santé et de la Recherche Médicale - Faculté de Médecine 8, rue du Général Sarrail 94000 Creteil

Radioactive cerium is a nuclear toxicant. Metallic cerium is used in industry. Aspects of the intracellular metabolism of this element were studied following intraperitoneal injection and aerosol exposure in rat. Two microanalytic methods, an electron microprobe and ionic microanalysis, enabled the sites of incorporation and the process of intracellular concentration of cerium to be determined in the liver, lung, kidney, bone marrow and bone tissue. The very high sensitivity of ionic analysis enabled very low concentrations of cerium to be detected with a spatial resolution of 0.5 µm. Microanalysis by electron microprobe permitted: (i) the lysosomal localization of cerium to be determined; and (ii) the lysosomal coprecipitation of cerium with phosphorus to be demonstrated. Results are discussed in relation to aspects of radiological protection.

Human & Experimental Toxicology, Vol. 8, No. 6, 511-520 (1989)
DOI: 10.1177/096032718900800614
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