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The Rarity of Liver Toxicity in Patients Treated with Coumarin (1, 2-Benzopyrone)

School of Biological Sciences, National Institute for Higher Education, Glasnevin, Dublin 9

R. O'Kennedy

School of Biological Sciences, National Institute for Higher Education, Glasnevin, Dublin 9

R.D. Thornes

Beaumont Hospital, Dublin 9, Ireland

1 Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial.

2 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin.

3 This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.

Human & Experimental Toxicology, Vol. 8, No. 6, 501-506 (1989)
DOI: 10.1177/096032718900800612


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