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Monitoring of Patients taking Canthaxanthin and Carotene: An Electroretinographic and Ophthalmological Survey

Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK

J.O.A. Oluwole

Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK

P. Polkinghorne

Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK

A.C. Bird

Electrodiagnostic Department, Moorfields Eye Hospital and Department of Clinical Ophthalmology, Institute of Ophthalmology, London, UK

F.M. Barker

Pennsylvania College of Optometry Philadelphia, USA

P.G. Norris

Department of Dermatology, St. Thomas' Hospital, London, UK

J.L.M. Hawk

Department of Dermatology, St. Thomas' Hospital, London, UK

1 Patients who have taken canthaxanthin and beta-carotene to avert phototoxicity have been monitored by electroretinographic testing.

2 Patients took the compounds only during the summer months, but were monitored for more than 1 year to determine if seasonal changes in the ERG were visible.

3 The characteristic refractile retinal crystals reduced during the winter.

4 The scotopic b-wave amplitude increased during the winter, whether evoked by red or blue flashes.

5 No other ERG parameter altered.

6 Changes noted in 3 and 4 above are reversible.

7 A dose/ERG-amplitude response relationship was established, but no correlation between blood level or total cumulative dose and b-wave amplitude could be found.

8 It is suggested that the Müller cells concentrate canthaxanthin and this is the mechanism which affects the ERG.

Human & Experimental Toxicology, Vol. 8, No. 6, 439-450 (1989)
DOI: 10.1177/096032718900800603


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