This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Averbukh, Z. Articles by Rosenmann, E. Search for Related Content PubMed Articles by Averbukh, Z. Articles by Rosenmann, E. Social Bookmarking                         What's this?

Rhabdomyolysis and Acute Renal Failure Induced by Paraphenylenediamine

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

D. Modai

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

Y. Leonov

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

J. Weissgarten

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

G. Lewinsohn

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

L. Fucs

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

A. Golik

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

E. Rosenmann

Departments of Nephrology, Critical Care Unit and Medicine A, Assaf Harofeh Medical Center, Zerifin, Departments of Pathology, Hadassah Medical Center, Jerusalem, Israel

1 We present a 40-year-old healthy man who developed a typical clinical picture of rhabdomyolysis following the administration of paraphenylenediamine by a witchdoctor as a pain killer.

2 Two groups of 15 mice were given paraphenylenediamine 70 mg/kg and 35 mg/kg respectively. Biochemical and histological findings of rhabdomyolysis developed in both groups, without kidney damage.

3 Paraphenylenediamine may cause rhabdomyolysis resulting in acute renal failure in humans. In mice, however, it produces rhabdomyolysis, but the kidneys are not affected.

Human & Experimental Toxicology, Vol. 8, No. 5, 345-348 (1989)
DOI: 10.1177/096032718900800502


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?