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Human & Experimental Toxicology
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Acute Resin Phenol-formaldehyde Intoxication. A Life Threatening Occupational Hazard

N. Cohen

Department of Medicine A, Assaf Harofeh Medical Center, Affiliated to the Sackler School of Medicine, Tel-Aviv University, Zerifin 70300, Israel

D. Modai

Department of Medicine A, Assaf Harofeh Medical Center, Affiliated to the Sackler School of Medicine, Tel-Aviv University, Zerifin 70300, Israel

A. Khahil

Department of Medicine A, Assaf Harofeh Medical Center, Affiliated to the Sackler School of Medicine, Tel-Aviv University, Zerifin 70300, Israel

A. Golik

Department of Medicine A, Assaf Harofeh Medical Center, Affiliated to the Sackler School of Medicine, Tel-Aviv University, Zerifin 70300, Israel

1 A 38-year-old previously healthy worker accidentally spilled phenol-formaldehyde resin over a large area of his skin.

2 Several days later he was hospitalized with extensive necrotic skin lesions, fever, hypertension, adult respiratory distress syndrome (ARDS), proteinuria and renal functional impairment.

3 All symptoms improved progressively and eventually disappeared.

4 We propose that toxic materials originating from the necrotic skin lesions and the continued facilitated absorption of the resin and/or its components via the skin lesions were the main factors responsible for this alarming multisystem involvement.

5 Workers handling this material should be instructed to take appropriate precautions and physicians should be alerted to the potential pathophysiological consequences.

Human & Experimental Toxicology, Vol. 8, No. 3, 247-250 (1989)
DOI: 10.1177/096032718900800308
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