This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Abrams, S.M.L. Articles by Turner, P. Search for Related Content PubMed Articles by Abrams, S.M.L. Articles by Turner, P. Social Bookmarking                         What's this?

Pharmacokinetic Interaction Between Indoramin and Ethanol

Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE

D.M. Pierce

Drug Metabolism and Pharmacokinetics Section, Wyeth Research (UK) Ltd., Huntercombe Lane South, Taplow, Maidenhead, Berks, SL6 OPH, UK

A. Johnston

Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE

A. Hedges

Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE

R.A. Franklin

Drug Metabolism and Pharmacokinetics Section, Wyeth Research (UK) Ltd., Huntercombe Lane South, Taplow, Maidenhead, Berks, SL6 OPH, UK

P. Turner

Department of Clinical Pharmacology, St Bartholomew's Hospital, London, EC1A 7BE

1 The effect of ethanol consumption (0.5 g/kg) on the pharmacokinetics of the alpha adrenoceptor antagonist indoramin, administered orally (50 mg) or intravenously (0.175 mg/kg) has been investigated in young volunteers. Sedation was also assessed using a visual analogue scale.

2 After oral indoramin administration, ethanol caused increases of 58% (P <0.01) in C_Pmax , and 25% (P <0.05) in AUC. There was no effect of alcohol on elimination half-life. The combination of ethanol and indoramin was more sedative than indoramin alone.

3 Ethanol did not alter the pharmacokinetics of an intravenous dose of indoramin. However indoramin caused a small but statistically significant increase (26%) in blood ethanol concentrations during the first 1.25 h after dosing. Both indoramin and ethanol caused sedation.

4 The increased bioavailability of oral indoramin in the presence of ethanol may reflect some enhanced absorption, but it is also consistent with inhibition of first-pass metabolism of a flow-limited drug. The clinical implications are discussed.

Human & Experimental Toxicology, Vol. 8, No. 3, 237-241 (1989)
DOI: 10.1177/096032718900800306


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?