SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Edvinsson, L.
Right arrow Articles by Monti, M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Edvinsson, L.
Right arrow Articles by Monti, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Effects of Calcium Entry Blockers on Human Platelet Metabolism Measured by Microcalorimetry

L. Edvinsson

Department of Internal Medicine, University Hospital, Lund, Sweden

J. Ikomi-Kumm

Department of Internal Medicine, University Hospital, Lund, Sweden

M. Monti

Department of Internal Medicine, University Hospital, Lund, Sweden

1 The direct overall metabolic effects of calcium entry blockers on human platelets were evaluated using a sensitive microcalorimetric method.

2 The effect on platelet metabolism of four calcium entry blockers with different profiles of action was examined and compared with the relaxant response on human cerebral vessels in vitro.

3 Diltiazem (10 -8, 10-4 M) and nifedipine (10-10, 10-6M) were without effect on overall platelet metabolism. On the other hand flunarizine (10-4M) and verapamil (10-4M) significantly reduced metabolism, while lower concentrations of these agents did not change heat production.

4 The thermogenic response occurred at concentrations of the calcium entry blockers that were much higher than those observed during therapy and the concentrations which relax human cerebral arteries in vitro.

Human & Experimental Toxicology, Vol. 8, No. 2, 131-133 (1989)
DOI: 10.1177/096032718900800208
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement