SAGE Journals Online
Advertisement
Sign In to gain access to subscriptions and/or personal tools.

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Advertisement

Sign In to gain access to subscriptions and/or personal tools.
Human & Experimental Toxicology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Nagao, M.
Right arrow Articles by Akabane, H.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Nagao, M.
Right arrow Articles by Akabane, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Immunotherapy for the Treatment of Acute Paraquat Poisoning

M. Nagao

Department of Legal Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan

T. Takatori

Department of Legal Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan

B. Wu

Department of Legal Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan

K. Terazawa

Department of Legal Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan

H. Gotouda

Department of Legal Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan

H. Akabane

Department of Legal Medicine, Hokkaido University School of Medicine, Sapporo 060, Japan

For the purpose of sequestering paraquat in the plasma compartment and preventing it from accumulating in tissues the effects of intravenous administration of anti-paraquat antibodies to rats were studied. After an intravenous paraquat injection of 0.1 mg/kg, the plasma paraquat concentration from rats pretreated with anti-paraquat antibodies was significantly increased and the amount of paraquat excreted in urine was significantly decreased compared to the control group. The concentration of paraquat in bile and organs except liver, was not changed by the treatment, but the paraquat level in the liver was significantly increased. Although immunotherapy succeeded in sequestering paraquat in the plasma compartment, it could not prevent paraquat from accumulating in tissues.

Human & Experimental Toxicology, Vol. 8, No. 2, 121-123 (1989)
DOI: 10.1177/096032718900800206
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




Advertisement