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Ranitidine Fails to Suppress the Growth in vitro of Haemopoietic Progenitors from Human Peripheral Blood or Bone Marrow

Section of Haematology, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex, HA1 3UJ, UK

A. Kirk

Section of Haematology, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex, HA1 3UJ, UK

Ranitidine was added in various concentrations (25-1600 ng/ml) to clonal assays of haemopoietic progenitors of normal human peripheral blood or bone marrow. Although a significant reduction in colonies forming from granulocyte-macrophage progenitors (CFU-GM) was demonstrated at the lowest drug concentration, no significant growth suppression was seen at higher concentrations. There was no evidence for growth inhibition of either erythroid progenitors (BFU-E) or pluripotent progenitors (CFU-mix) at any of the drug concentrations studied. A direct toxic effect of ranitidine on normal haemopoietic progenitors thus appears an unlikely cause of cytopenias observed during treatment.

Human & Experimental Toxicology, Vol. 8, No. 1, 19-22 (1989)
DOI: 10.1177/096032718900800104


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