This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Webb, D.B. Articles by Wallis, D.I. Search for Related Content PubMed Articles by Webb, D.B. Articles by Wallis, D.I. Social Bookmarking                         What's this?

An Electrophysiological Study of Ganglion Blockade by Paraquat and Diquat

Princess of Wales Hospital, Coity Road, Bridgend, CF31 1RQ, Department of Physiology, University College, Cardiff, UK

E.J. Ansari

Princess of Wales Hospital, Coity Road, Bridgend, CF31 1RQ, Department of Physiology, University College, Cardiff, UK

D.I. Wallis

Princess of Wales Hospital, Coity Road, Bridgend, CF31 1RQ, Department of Physiology, University College, Cardiff, UK

1 The bipyridilium herbicides, particularly paraquat, have chemical and toxicological features in common with the bi-quaternary ammonium ganglion blockers.

2 Paraquat and diquat were tested for ganglion blocking activity. Rabbit cervical ganglia were superfused with both agents and subsequently with hexamethonium to confirm susceptibility to ganglion blockade.

3 No evidence for ganglion blockade was found at either supra maximal or sub maximal stimulation, and none following repetitive stimulation.

4 The similarities and differences between the bipyridyl herbicides and bi-quaternary ganglion blockers can be explained on the basis of their structures.

5 It is concluded that neither paraquat nor diquat have significant ganglion blocking activity.

Human & Experimental Toxicology, Vol. 7, No. 6, 563-565 (1988)
DOI: 10.1177/096032718800700609


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?