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Human & Experimental Toxicology
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Toxicity of Astatine-211 in the Mouse

L.M. Cobb

Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Harwell, Didcot, Oxon. OX11 0RD, UK

A. Harrison

Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Harwell, Didcot, Oxon. OX11 0RD, UK

S.A. Butler

Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Harwell, Didcot, Oxon. OX11 0RD, UK

The toxicity of the {alpha} particle emitting halogen astatine-211 was examined in male and female mice. Pathological changes were seen in mice killed at 14 days and/or at 56 days following a single injection of 61 kBq211 At per g body weight. The tissues affected, in order of severity were: spleen, lymph nodes, bone marrow, gonads, thyroid, salivary glands and stomach.

Human & Experimental Toxicology, Vol. 7, No. 6, 529-534 (1988)
DOI: 10.1177/096032718800700602
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