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Reproductive Toxicity Tests: Retrospect and Prospect

Department of Pharmacology and Toxicology, United Medical & Dental Schools, Guy's Hospital Campus, London, SE1 9RT, UK

1 The design of the classical three segment reproductive test for new drugs is described and the relative merits of the USA/EEC and the Japanese guidelines are discussed.

2 The importance of pharmacokinetic studies in the interpretation of teratology studies and extrapolation to humans is mentioned in relation to caffeine, sodium valproate and cyclophosphamide.

3 Changing ideas on the design of multi-generation studies are reviewed.

4 Recent developments in the fields of behavioural teratology, chemicals in breast milk and transplacental carcinogenesis are described.

Human & Experimental Toxicology, Vol. 7, No. 5, 423-427 (1988)
DOI: 10.1177/096032718800700507


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