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Allopurinol Kinetics after Massive Overdosage

Regional Clinical Pharmacology Unit, Freeman Hospital, Newcastle upon Tyne NE7 7DN

H.A. Simmonds

Purine Research Laboratory Guy's Hospital, London SE1 9RT, UK

D.N. Bateman

Regional Clinical Pharmacology Unit, Freeman Hospital, Newcastle upon Tyne NE7 7DN

A 15-year-old girl with normal renal function took 75 tablets of allopurinol 300 mg. She did not suffer any ill-effects. Samples obtained over 84 h showed prolonged elimination of allopurinol, with a half-life of 3.6 h, and oxipurinol, with a half-life of 26 h.

Human & Experimental Toxicology, Vol. 7, No. 3, 293-294 (1988)
DOI: 10.1177/096032718800700313


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