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Acute MCPP Intoxication: Report of Two Cases

National Poison Control Centre of the National Institute of Public Health and Environmental Hygiene, P.O. Box 1, 3720 BA, Bilthoven, Department of Reanimation and Clinical Toxocology, University Hospital Utrecht

J.H. Zwaveling

National Poison Control Centre of the National Institute of Public Health and Environmental Hygiene, P.O. Box 1, 3720 BA, Bilthoven, Department of Reanimation and Clinical Toxocology, University Hospital Utrecht

P. van Zoonen

Laboratory of Organic and Analytical Chemistry of the National Institute of Public Health and Environmental Hygiene, Bilthoven

N.C. Notermans

Department of Neurology, University Hospital Utrecht, The Netherlands

1 Two cases of serious intoxication with phenoxy herbicides (MCPP) are reported.

2 Both patients had central nervous system involvement, became unconscious and had an inadequate respiration. Muscle cramps and rhabdomyolysis with renal failure were noted in both. Shortly after admission both patients developed a serious decrease in arterial blood pressure (160/ 80 mmHg to 80/45 mmHg). In one patient this was demonstrated to be caused by a reduction in peripheral vascular resistance.

3 Plasma concentration of MCPP in patient 2 was 298 mg/l (3-4 h after ingestion). The plasma t was about 17 h. MCPP plasma elimination probably follows first-order kinetics.

Human & Experimental Toxicology, Vol. 7, No. 3, 289-292 (1988)
DOI: 10.1177/096032718800700312


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