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Influence of Age and Consumption of Tobacco, Alcohol and Caffeine on Antipyrine Clearance

Department of Pharmacology, University of Copenhagen and Department of Medicine P, Bisbebjerg Hospital, Copenhagen, Denmark

M. Døssing

Department of Pharmacology, University of Copenhagen and Department of Medicine P, Bisbebjerg Hospital, Copenhagen, Denmark

H.E. Poulsen

Department of Pharmacology, University of Copenhagen and Department of Medicine P, Bisbebjerg Hospital, Copenhagen, Denmark

1 Antipyrine clearance and average daily consumption of tobacco, alcohol and coffee/tea were determined in 303 healthy men.

2 The antipyrine clearance was positively correlated with the consumption of tobacco (r = 0.24; P < 0.0001) and coffee/tea (r = 0.18; P < 0.001), and negatively with age (r = -0.14; P < 0.05) and the alcohol consumption (r = —0.13; P < 0.05).

3 The multiple regression coefficients suggested an increase in antipyrine clearance of 0.8% per daily cigarette or cup of tea and 1.4% per daily cup of coffee; the decrease per daily drink or year of age was 2.8% or 0.4%, respectively.

Human & Experimental Toxicology, Vol. 7, No. 3, 277-280 (1988)
DOI: 10.1177/096032718800700309


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