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Comparative Effects of Several Chelating Agents on the Toxicity, Distribution and Excretion of Aluminium

Laboratory of Toxicology and Biochemistry, School of Medicine, C/San Llorenç 21,43201-Reus

M. Gómez

Laboratory of Toxicology and Biochemistry, School of Medicine, C/San Llorenç 21,43201-Reus

J.M. Llobet

Laboratory of Toxicology and Biochemistry, School of Medicine, C/San Llorenç 21,43201-Reus

J. Corbella

Department of Toxicology, School of Medicine, University of Barcelona, C/Casanova 143, 08036-Barcelona, Spain

The relative efficacy of citric, malic, malonic, oxalic and succinic acids, and deferoxamine mesylate (DFOA) on the toxicity, distribution and excretion in mice exposed to aluminium were compared. Chelating agents were administered intraperitoneally at a dose equal to one-fourth of their respective LD₅₀. To determine the effect of the various chelators on the toxicity of aluminium, various doses of aluminium nitrate (938-3188 mg/kg) were administered intraperitoneally, followed by one of the chelators. Survival was recorded at the end of 14 days. Malic and succinic acids were the most effective.

Malic acid and DFOA were the most effective in increasing the urinary excretion of aluminium. Citric acid was the most effective in increasing the faecal excretion of aluminium. Malonic, oxalic and succinic acids had no overall beneficial effects. Citric acid would appear to be the most effective agent of those tested in the prevention of acute aluminium intoxication. However, before the use of these compounds in human aluminium intoxication is possible, further investigations including the effects of these chelators after chronic aluminium intoxication are required.

Human & Experimental Toxicology, Vol. 7, No. 3, 259-262 (1988)
DOI: 10.1177/096032718800700305


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