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Human & Experimental Toxicology
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Is There a Central Nervous Withdrawal Syndrome Associated with Discontinuing Long-term Treatment with Propranolol?

H. Al-Qassab

Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, EC1A 7BE

L.A. Cleeves

MRC Neuro-Otology Unit, Institute of Neurology, National Hospital, Queen Square, London WC1N 3BG

P.L. Francis

Department of Reproductive Physiology, St. Bartholomew's Hospital Medical College, London EC1A 7BE, UK

M.R. Al-Sereiti

Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, EC1A 7BE

L. Findley

MRC Neuro-Otology Unit, Institute of Neurology, National Hospital, Queen Square, London WC1N 3BG

A. Hedges

Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, EC1A 7BE

R. Silman

Department of Reproductive Physiology, St. Bartholomew's Hospital Medical College, London EC1A 7BE, UK

P. Turner

Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, EC1A 7BE

Thirty healthy volunteers were treated with beta-adrenoceptor blocking doses of long-acting propranolol for at least 28 days before being randomized to continue propranolol treatment, receive identical placebo under double-blind conditions, or discontinue all treatment. No evidence of a central nervous withdrawal syndrome occurred during the next 28 days as assessed by changes in psychomotor tests, rating scales, visual analogue scales, tremor recordings and melatonin excretion. Three subjects in the placebo withdrawal group but none in the propranolol group complained of insomnia for up to 14 days of the withdrawal period.

Human & Experimental Toxicology, Vol. 7, No. 3, 249-254 (1988)
DOI: 10.1177/096032718800700303
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