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Human & Experimental Toxicology
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The Effects of Soman on Human Isolated Uterine Arteries

C.-Y. Hu

College of Pharmacy, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73190, USA

C.P. Robinson

College of Pharmacy, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73190, USA

1 The effects of soman on the resting contractile tension of human uterine arteries, and on contractions of these arteries to vasoactive agents were investigated.

2 Soman did not alter the resting tension of helically-cut strips of human uterine arteries.

3 Soman did not alter concentration-response curves of the strips to noradrenaline, serotonin, potassium chloride or histamine.

4 Soman increased contractile tension of human uterine artery strips to subsequently added 1 µM noradrenaline.

5 It is possible that this enhancement may be involved in decreased regional blood flow following soman administration.

Human & Experimental Toxicology, Vol. 7, No. 2, 141-144 (1988)
DOI: 10.1177/096032718800700206


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