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The Metabolism of Ceramic and Non-ceramic Forms of Uranium Dioxide after Deposition in the Rat Lung

National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 ORQ

J.W. Stather

National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 ORQ

S.A. Gray

National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 ORQ

J.C. Moody

National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 ORQ

A. Hodgson

National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 ORQ

D. Sedgwick

British Nuclear Fuels plc, Springfield Works, Salwick, Preston, Lancs PR4 0XJ, UK

N. Cooke

British Nuclear Fuels plc, Springfield Works, Salwick, Preston, Lancs PR4 0XJ, UK

Ceramic and non-ceramic forms of uranium dixoide, produced industrially, were administered to rats either by inhalation or as an aqueous suspension which was injected directly into the pulmonary region of the lungs. The results showed that:

1 both materials should be assigned to inhalation class Y as defined by the International Commission on Radiological Protection;

2 whilst the translocation of uranium to the blood for the non-ceramic UO₂ was about twice that obtained for the ceramic form, the two dioxides were unlikely to be differentiated on the basis of their lung retention kinetics;

3 the distribution of uranium amongst body tissues and the relationship between systemic content and cumulative urinary excretion indicated that it was transported in the hexavalent form;

4 in addition to air sampling procedures, lung radioactivity counting measurements could be used to advantage for assessing occupational exposures;

5 the exposure limits should be based on radiation dose rather than chemical toxicity.

Human & Experimental Toxicology, Vol. 7, No. 2, 133-139 (1988)
DOI: 10.1177/096032718800700205


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