This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Siefkin, A.D. Articles by Corbett, M.G. Search for Related Content PubMed Articles by Siefkin, A.D. Articles by Corbett, M.G. Social Bookmarking                         What's this?

Isoniazid Overdose: Pharmacokinetics and Effects of Oral Charcoal in Treatment

Department of Internal Medicine, Divisions of Pulmonary Medicine, Emergency Medicine, Clinical Toxicology and Sections of Critical Care Medicine, University of California Davis, School of Medicine and University of California, Davis Medical Center (UCDMC), Sacramento, California 98517, USA

T.E. Albertson

Department of Internal Medicine, Divisions of Pulmonary Medicine, Emergency Medicine, Clinical Toxicology and Sections of Critical Care Medicine, University of California Davis, School of Medicine and University of California, Davis Medical Center (UCDMC), Sacramento, California 98517, USA

M.G. Corbett

Department of Internal Medicine, Divisions of Pulmonary Medicine, Emergency Medicine, Clinical Toxicology and Sections of Critical Care Medicine, University of California Davis, School of Medicine and University of California, Davis Medical Center (UCDMC), Sacramento, California 98517, USA

The pharmacokinetics of isoniazid following overdose in two patients is described. One patient was treated with haemodialysis for seizures and persistent coma without obvious immediate clinical improvement. In addition, three volunteer subjects were given isoniazid orally on two separate occasions. Isoniazid elimination pharmacokinetics were determined with and without concominant charcoal. Oral activated charcoal totally prevented the absorption of isoniazid. Current recommendations for treatment of isoniazid overdoses include intravenous pyridoxine (one gram IV pyridoxine for each gram of ingested isoniazid), intravenous diazepam or phenobarbital for continued seizures, and gastric decontamination with lavage and activated charcoal (1 g/kg). Extraordinary measures such as early haemodialysis and haemoperfusion should be reserved for those patients with persistent coma or refractory seizures.

Human & Experimental Toxicology, Vol. 6, No. 6, 497-501 (1987)
DOI: 10.1177/096032718700600608


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?