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A Study of the Effect of Decimal and Centesimal Dilutions of Arsenic on the Retention and Mobilization of Arsenic in the Rat

Laboratoire de Pharmacologie, Facult� de Pharmacie, 3 rue Laguesse 59045, Lille C�dex

M. Cazin

Laboratoire de Pharmacologie, Facult� de Pharmacie, 3 rue Laguesse 59045, Lille C�dex

J.L. Gaborit

Laboratoire de Pharmacologie, Facult� de Pharmacie, 3 rue Laguesse 59045, Lille C�dex

A. Chaoui

Laboratoire de Pharmacologie, Facult� de Pharmacie, 3 rue Laguesse 59045, Lille C�dex

J. Boiron

Laboratoires Boiron, 20 rue de la Liberation, 69110 Ste-Foy-Les-Lyon

P. Belon

Laboratoires Boiron, 20 rue de la Liberation, 69110 Ste-Foy-Les-Lyon

Y. Cherruault

Universit� Paris 6, M�dimat, 15 rue de l'Ecole de Medicine, 75270 Paris C�dex 06, France

C. Papapanayotou

Universit� Paris 6, M�dimat, 15 rue de l'Ecole de Medicine, 75270 Paris C�dex 06, France

Having developed a pharmacokinetic method for studying the fate of orally administered arsenious anhydride by a radioactive tracer method, the influence of Hahnemannian dilutions of arsenicum album on the elimination and retention of this toxin in the rat was then investigated. The effects of centesimal (cH) and decimal (dH) dilutions were studied.

All the dilutions studied were found to be active. The strongest effects were observed after the administration of dilutions corresponding to a concentration of 10-14 (14dH and 7cH). Overall, the decimal dilutions augmented the elimination of arsenic more than the centesimals.

The observed results were submitted to mathematical analysis. A mathematical model, which confirms that Hahnemannian dilutions have biological effects which are a direct function of the degree of dilution, was developed.

Human & Experimental Toxicology, Vol. 6, No. 4, 315-320 (1987)
DOI: 10.1177/096032718700600408


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