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Human & Experimental Toxicology
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Nomifensine and Convulsive Seizures

J. Guy Edwards

Department of Psychiatry, Royal South Hampshire Hospital, Southampton, SO9 4PE

M. Glen-Bott

Medicines Division, Department of Health and Social Security, Market Towers, London, SW8 5NQ, UK

Four cases of convulsive seizures occurring during treatment with nomifensine have been notified to the Committee on the Safety of Medicines of the United Kingdom, and 22 cases have been reported from other countries. The occurrence of convulsions is not in keeping with the results of animal experiments, studies of epileptic patients treated with nomifensine or observations made following overdoses of this drug. Nomifensine may thus not be entirely free from epileptogenic properties as previously presumed.

Human & Experimental Toxicology, Vol. 6, No. 3, 247-249 (1987)
DOI: 10.1177/096032718700600314
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