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Carbamazepine and Carbamazepine-10,11-epoxide Pharmacokinetics in an Overdose Patient

Department of Chemical Pathology, The National Hospital, Queen Square, London WC1N 3BG, Chalfont Centre for Epilepsy, Chalfont St Peter, Gerrards Cross, Buckinghamshire SL9 ORJ

S. Krishna

Wexham Park Hospital, Slough SL2 4HL, UK

A.A. Elyas

Department of Chemical Pathology, The National Hospital, Queen Square, London WC1N 3BG

P.T. Lascelles

Department of Chemical Pathology, The National Hospital, Queen Square, London WC1N 3BG

1 A case report on a 13-year-old girl with idiopathic grand mal epilepsy who ingested 34 g carbamazepine (CBZ) and 80 mg clonazepam is presented.

2 The patient survived but suffered severe temporary neurological toxicity characteristic of CBZ.

3 CBZ was 79.6 ± 2.8% bound to serum protein and carbamazepine-10,11-epoxide (CBZ-E) binding was essentially concentration dependent.

4 CBZ and CBZ-E elimination half-lives were 26 and 16.5 h respectively. An inhibitory metabolic interaction with the co-ingested clonazepam is suggested.

Human & Experimental Toxicology, Vol. 6, No. 3, 241-244 (1987)
DOI: 10.1177/096032718700600312


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