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Human & Experimental Toxicology
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Evidence for Lipid Peroxidation in Man Following Paraquat Ingestion

R.D. Situnayake

The Clinical Investigation Unit, Department of Medicine, Dudley Road Hospital, Birmingham, B18 7QH, UK

B.J. Crump

The Clinical Investigation Unit, Department of Medicine, Dudley Road Hospital, Birmingham, B18 7QH, UK

D.I. Thurnham

Affiliated to: Wolfson Research Laboratory, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK

J.A. Davies

Affiliated to: Wolfson Research Laboratory, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK

M. Davis

The Clinical Investigation Unit, Department of Medicine, Dudley Road Hospital, Birmingham, B18 7QH, UK

1 Four patients were investigated for evidence of lipid peroxidation between 4.5 and 36 h (mean 22 h) after ingestion of paraquat by measuring plasma phospholipid-2-esterified, diene-conjugated 18:2{Delta}9,11-linoleic acid (9,11-LA) and expressing it also as a ratio R (9,11-LA/9,12-LA x 100) of the 'parent' linoleic acid.

2 The mean value for R was 4.73 (range 3.7-7.1) at presentation and 6.91 at peak values (range 3.8-13.4) which occurred at a mean of 34 h after ingestion. Both values were significantly higher (P < 0.001) than that of 107 healthy controls (1.94, range 0.67-3.8).

3 Parallel changes in plasma vitamin E and 9,11-LA occurred in the 2 patients in whom serial measurements were made suggesting an involvement of vitamin E in the formation of this isomer.

4 These findings support the hypothesis that lipid peroxidation occurs during paraquat poisoning in man and the early appearance of 9,11-LA suggests that it may be a primary event.

Human & Experimental Toxicology, Vol. 6, No. 1, 94-98 (1987)
DOI: 10.1177/096032718700600117
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