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The Effectiveness of a Cation Resin (Kayexalate) as an Adsorbent of Paraquat: Experimental and Clinical Studies

Institute of Clinical Medicine, University of Tsukuba and Department of Pharmacy, University Hospital of Tsukuba,Japan

H. Naito

Institute of Clinical Medicine, University of Tsukuba and Department of Pharmacy, University Hospital of Tsukuba,Japan

S. Takagi

Institute of Clinical Medicine, University of Tsukuba and Department of Pharmacy, University Hospital of Tsukuba,Japan

1 The cation-exchange-resin Kayexalate^R has an adsorption capacity for paraquat 15 times greater than activated charcoal and 6 times greater than Adsorbin. The oral LD ₅₀ of paraquat in rats rose 2.1 times by intragastric injection of Kayexalate.¹

2 In the present study, the survival rate of rats given Kayexalate or Adsorbin after paraquat administration was examined. Results of clinical studies on 22 patients are also presented.

Human & Experimental Toxicology, Vol. 6, No. 1, 89-90 (1987)
DOI: 10.1177/096032718700600115


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