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Pharmacological Treatments of Paraquat Poisoning

Freeman Hospital, Newcastle upon Tyne NE7 7ND, UK

1 A large number of pharmacological techniques aimed at modifying paraquat toxicity have been investigated. There is no convincing controlled evidence that any are unequivocally useful.

2 Studies with an ascorbic acid and riboflavin combination appear effective in rats, and there is a suggestion that cyclophosphamide and dexamethasone may in some way alter paraquat toxicity in man and by pretreatment, but not concurrent treatment, also in the rat.

3 Further controlled studies are required of these treatments in patients who are potentially salvageable. There is a need for a rapid paraquat assay for clinical use in order that patients in this category can be identified quickly and included in appropriate controlled studies.

Human & Experimental Toxicology, Vol. 6, No. 1, 57-62 (1987)
DOI: 10.1177/096032718700600109


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