This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Davies, D.S. Search for Related Content PubMed Articles by Davies, D.S. Social Bookmarking                         What's this?

Paraquat Poisoning: The Rationale for Current Treatment Regimes

Department of Clinical Pharmacology, Royal Postgraduate Medical School, Du Cane Road, London W12 OHS, UK

1 The critical events leading to death from the ingestion of paraquat are absorption from the gastrointestinal tract, active accumulation in the lung almost certainly preceded by acute renal failure and redox cycling in the lung which initiates certain, as yet unidentified, biochemical events leading to cell death with subsequent destruction of the lung and death from anoxia.

2 Present evidence suggests that absorption of paraquat is rapid and the use of adsorbents more than 6 hours after ingestion is likely to be ineffective. Further work is needed to characterize the mechanism of absorption and to identify an innocuous chemical which could be added to formulations of paraquat to inhibit absorption; this approach may be the best solution to the problem of paraquat poisoning.

3 Steps to actively remove paraquat from the systemic circulation will probably only succeed in a small number of patients taking moderate doses and developing early renal failure. The 'window' for such treatment may be as narrow as 6-18 h after ingestion. This 'window' would also operate for chemicals designed to inhibit the pulmonary uptake of paraquat.

4 The biochemical events leading to paraquat-induced cell death are not sufficiently defined to permit the design of treatments to prevent or reverse these processes.

Human & Experimental Toxicology, Vol. 6, No. 1, 37-40 (1987)
DOI: 10.1177/096032718700600106


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?