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Seventh-nerve Palsy and Hepatitis Associated with Nitrofurantoin

Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK

O.F.W. James

Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne, Newcastle NE1 7RU, UK

Adverse hepatic reactions to nitrofurantoin therapy are well reported and range from acute cholestatic or hepatitic injury to chronic active hepatitis [R. G. Penn & J. P. Griffin (1982) Br. Med. J., 284, 1440-1442]. Neurological side-effects, predominantly sensorimotor peripheral poly-neuropathy, have also been documented [R. G. Penn & J. P. Griffin (1982)]. We report the first case of combined neurological and hepatic reaction to nitrofurantoin; this occurred during repeated treatment with the drug.

Human & Experimental Toxicology, Vol. 5, No. 6, 387-388 (1986)
DOI: 10.1177/096032718600500611


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