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Charcoal-column Haemoperfusion does not Significantly Enhance Chlormethiazole Removal

Regional Clinical Pharmacology Unit

A. Pottage

Astra Clinical Research Unit, 10 York Place, Edinburgh EH1 3EP, Scotland, UK

D.W. Ryan

General Intensive Care Unit, Freeman Hospital, Newcastle upon Tyne NE7 7DN

D.N. Bateman

Regional Clinical Pharmacology Unit

A 26-year-old man had convulsions after taking an overdose of slow-release aminophylline tablets. The convulsions were treated with an infusion of chlormethiazole and theophylline was removed by charcoal-column haemoperfusion. It has been suggested that haemoperfusion might be useful for removing chlormethiazole and this was investigated. There was no evidence that charcoal-column haemoperfusion could remove clinically significant amounts of chlormethiazole.

Human & Experimental Toxicology, Vol. 5, No. 6, 367-368 (1986)
DOI: 10.1177/096032718600500605


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