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Human & Experimental Toxicology
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Blood Lactate and Ketone Body Concentrations in Salicylate Intoxication

P.D. Bartels

Poisoning Treatment Centre, Departments of Medicine C and Clinical Chemistry, Bispebjerg Hospital, DK 2400, Copenhagen N.V., Denmark

H. Lund-Jacobsen

Poisoning Treatment Centre, Departments of Medicine C and Clinical Chemistry, Bispebjerg Hospital, DK 2400, Copenhagen N.V., Denmark

1 Blood concentrations of lactate, ketone bodies and non-esterified (free) fatty acids were measured in 45 adult patients on admission to the poisoning treatment centre, with salicylate and mixed salicylate-sedative/ethanol poisoning.

2 Nine patients had blood lactate concentrations above 2 mmol/l and six patients had ketone-body concentrations greater than 1 mmol/l.

3 Eight of the nine patients with hyperlactacidaemia had mixed salicylate/ethanol or sedative poisoning, whereas four of the six patients with hyperketonaemia had pure salicylate poisoning.

4 No direct correlation was found between the presence of these metabolic disturbances and the severity of poisoning.

5 Since only one patient was found with organic acid concentration in the blood exceeding 5 mmol/l, it is concluded that concomitant endogenous acidosis rarely contributes to the acid-base disturbance seen in salicylate poisoning in adults.

Human & Experimental Toxicology, Vol. 5, No. 6, 363-366 (1986)
DOI: 10.1177/096032718600500604
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