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Human & Experimental Toxicology
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Comparison of Effects of Lysine Aspirin, Soluble Aspirin and Conventional Aspirin on Buccal Potential Difference in Healthy Volunteer Subjects

K. Shah

Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC1A 7BE, UK

S.H.D. Jackson

Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC1A 7BE, UK

A. Hedges

Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC1A 7BE, UK

P. Turner

Department of Clinical Pharmacology, St Bartholomew's Hospital, London EC1A 7BE, UK

The effects of aspirin, soluble aspirin and lysine aspirin on buccal mucosal potential difference (p.d.) were compared in a double-blind trial. Placebo and three doses of each preparation containing 150, 300 and 600 mg of aspirin were allocated according to a latin square design. Six volunteer subjects were studied; each received a total of 10 treatments at least 24 h apart. All doses of each preparation considered, a significant treatment effect was seen [F (d.f. = 2,306) = 6.2, P<0.003]. Lysine aspirin showed the least effect of the active treatments on buccal p.d. with a change from baseline of +8.5 mV compared with +13.3 for soluble aspirin +14.4 for conventional aspirin and —5.2 mV for placebo.

Human & Experimental Toxicology, Vol. 5, No. 5, 329-331 (1986)
DOI: 10.1177/096032718600500506
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