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Kinetics of Methaemoglobin Production (2). Kinetics of the Cyanide Antidote p-Aminopropiophenone During Oral Administration

Pathology and Clinical Toxicology Section, Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK

T.C. Marrs

Pathology and Clinical Toxicology Section, Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK

The kinetics of methaemoglobin production by orally administered p-aminopropiophenone (PAPP) was studied by using a kinetic model previously developed to describe methaemoglobinaemia consequent on intravenous injection of PAPP. Both ISIS, a simulation package, and NONLIN, a non-linear least-squares regression analysis program, were used to analyse the data. Some modification of the model was necessary to describe oral profiles and 40-50% of the administered PAPP appeared to be being metabolized at first pass to a non-active metabolite.

Human & Experimental Toxicology, Vol. 5, No. 5, 303-307 (1986)
DOI: 10.1177/096032718600500502


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