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Kinetics of Methaemoglobin Production (1)

Kinetics of Methaemoglobinaemia induced by the Cyanide Antidotes, p-Aminopropiophenone, p-Hydroxyaminopropiophenone or p-Dimethylaminophenol after Intravenous Administration

Pathology and Clinical Toxicology Section, Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK

J.E. Bright

Pathology and Clinical Toxicology Section, Chemical Defence Establishment, Porton Down, Salisbury, Wiltshire SP4 0JQ, UK

Methaemoglobin profiles have been studied by using ISIS, a simulation package, and NONLIN, a ion-linear least-squares analysis regression program. A simple kinetic model which satisfactorily describes methaemoglobin profiles after p-aminopropiophenone (PAPP) administration and 4-dimethylaminophenol (DMAP) administration has been developed. The two compounds differed nainly in their effective rates of elimination. The model less satisfactorily described methaemoglobin profiles after p-hydroxyaminopropiophenone (PHAPP) administration.

Human & Experimental Toxicology, Vol. 5, No. 5, 295-301 (1986)
DOI: 10.1177/096032718600500501


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